Figure 2. Kinetics of opening and closing for hNav1.9/Kv2.1 chimeric constructs. (A) Representative macroscopic currents showing channel activation (left) and channel deactivation (right) using the following voltage protocols: activation, 10-mV incrementing steps to voltages between −60 and +100 mV (−90 mV for DII) from a holding potential of −90 mV; deactivation, 10-mV incrementing steps to voltages between −10 and −100 mV (−150 mV for DII) from a test voltage of between +80 and +100 mV (holding potential is −90 mV). (B) Mean time constants (τ) from single-exponential fits to channel activation (filled circles) and deactivation (open circles) plotted as a function of the voltage at which the current was recorded. n = 4–8, and error bars represent SEM.
Figure 2.

Kinetics of opening and closing for hNav1.9/Kv2.1 chimeric constructs. (A) Representative macroscopic currents showing channel activation (left) and channel deactivation (right) using the following voltage protocols: activation, 10-mV incrementing steps to voltages between −60 and +100 mV (−90 mV for DII) from a holding potential of −90 mV; deactivation, 10-mV incrementing steps to voltages between −10 and −100 mV (−150 mV for DII) from a test voltage of between +80 and +100 mV (holding potential is −90 mV). (B) Mean time constants (τ) from single-exponential fits to channel activation (filled circles) and deactivation (open circles) plotted as a function of the voltage at which the current was recorded. n = 4–8, and error bars represent SEM.

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