Figure 2. The degree of MscS... | Rockefeller University Press

Figure 2.

$Figure 2. The degree of MscS inactivation is independent of the open period but increases with the time spent in the closed-adapted state. (A) Current responses to a double-step protocol in which the first saturating step (105 mmHg) of varied length is followed by a 10-s subsaturating step (75 mmHg). The responses to the short test pulse at the end indicate the fraction of active channels (numbers by the arrows). (B) The 30-s stimulus includes saturating (160 mmHg) and subsaturating (125 mmHg) pressure steps of reciprocally varying duration. The percentage of inactivation averaged over four patches studied with this protocol is shown in C (bars represent SD). The test ramp experiment (D) indicated the midpoint of 125 mmHg for the patch examined in B.$

The degree of MscS inactivation is independent of the open period but increases with the time spent in the closed-adapted state. (A) Current responses to a double-step protocol in which the first saturating step (105 mmHg) of varied length is followed by a 10-s subsaturating step (75 mmHg). The responses to the short test pulse at the end indicate the fraction of active channels (numbers by the arrows). (B) The 30-s stimulus includes saturating (160 mmHg) and subsaturating (125 mmHg) pressure steps of reciprocally varying duration. The percentage of inactivation averaged over four patches studied with this protocol is shown in C (bars represent SD). The test ramp experiment (D) indicated the midpoint of 125 mmHg for the patch examined in B.

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