Figure 3. Voltage-dependent inhibition of steady-state outward Na/K pump current by Nao. Inhibition in RD (A), C113Y (B), and WT (C) pumps. Ouabain-sensitive currents in 15 mM Ko, without (open symbols) or with (closed symbols) external Na, were obtained by appropriate subtraction of data shown in Fig. 2 (B–G). (D) To facilitate comparison among the different pumps, each ouabain-sensitive I-V relationship was normalized to its mean amplitude between 0 and 60 mV, and the normalized I-Vs for each pump type, with or without Nao, were then averaged.
Figure 3.

Voltage-dependent inhibition of steady-state outward Na/K pump current by Nao. Inhibition in RD (A), C113Y (B), and WT (C) pumps. Ouabain-sensitive currents in 15 mM Ko, without (open symbols) or with (closed symbols) external Na, were obtained by appropriate subtraction of data shown in Fig. 2 (B–G). (D) To facilitate comparison among the different pumps, each ouabain-sensitive I-V relationship was normalized to its mean amplitude between 0 and 60 mV, and the normalized I-Vs for each pump type, with or without Nao, were then averaged.

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