Figure 1.
Schematic diagram of ribosome biogenesis. In the nucleolus, RNA Pol I transcribes a polycistronic pre-rRNA, which is subsequently processed and modified into mature rRNAs (18S, 5.8S, and 28S). Another rRNA, 5S, is transcribed by RNA Pol III in the nucleoplasm. RNA Pol II transcribes snoRNAs (which aid the maturation of pre-rRNA) and mRNAs in the nucleus. mRNAs are transported to the cytoplasm and then translated by ribosomes. RPs and assembly factors (such as FBL and DKC) are also products of mRNA translation. RPs can be reimported to the nucleus to assemble pre40S/60S with rRNAs, which are then exported to the cytoplasm and matured to function in mRNA translation. Illustration by Jill K. Gregory.Fig. 1 is reprinted with permission from Mount Sinai Health System.

Schematic diagram of ribosome biogenesis. In the nucleolus, RNA Pol I transcribes a polycistronic pre-rRNA, which is subsequently processed and modified into mature rRNAs (18S, 5.8S, and 28S). Another rRNA, 5S, is transcribed by RNA Pol III in the nucleoplasm. RNA Pol II transcribes snoRNAs (which aid the maturation of pre-rRNA) and mRNAs in the nucleus. mRNAs are transported to the cytoplasm and then translated by ribosomes. RPs and assembly factors (such as FBL and DKC) are also products of mRNA translation. RPs can be reimported to the nucleus to assemble pre40S/60S with rRNAs, which are then exported to the cytoplasm and matured to function in mRNA translation. Illustration by Jill K. Gregory.Fig. 1 is reprinted with permission from Mount Sinai Health System.

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