Supplement to Fig. 4. Related to Fig. 4. (A) SILAC-based enrichment of PARylated proteins identified in WT nonstressed HeLa cells using either NEURL4 KO1 or KO2 cells as a background. (B) IP assay showing suppression of CPS1 PARylation in the absence of NEURL4. (C) Profiling of DEGs identified in NEURL4 KO1 and KO2 cells as compared with WT parental HeLa cells by RNA-seq and differential gene expression analysis by DESeq2. DEGs, differential expressed genes; ME, mitochondria extracts.