The fates of misfolded proteins in the ER. Most misfolded proteins in the ER are eliminated by ERAD via the ubiquitin-proteasome system. Some misfolded proteins exit the ER and are sorted to the lysosome/vacuole for degradation. Other misfolded proteins are transported to the lysosome/vacuole for degradation via ER-phagy. The three QC machineries act coordinately to safeguard ER proteostasis and are induced by the UPR (defined by red text).