![Figure 3. The GQC pathway in yeast. Misfolded proteins targeted for GQC are transported to the cis-Golgi via COPII vesicles. Proteasome-targeted GQC: ER chaperones (e.g., Kar2 [in pink]) and retrieval receptors (in blue) in the cis-Golgi bind and retrieve misfolded proteins to the ER in COPI vesicles. These substrates are eliminated by ERAD-L. Lysosome/vacuole–targeted GQC: misfolded proteins that migrate to the trans-Golgi are sorted by the ESCRT/MVB pathway via Vps10 (green) or a ubiquitin ligase (e.g., Tul1). Following sorting, misfolded proteins are delivered to the vacuole.](https://cdn.rupress.org/rup/content_public/journal/jcb/218/10/10.1083_jcb.201906047/8/jcb_201906047_fig3.jpeg?Expires=1767665917&Signature=h3qF2hf0yMlTzh51efXHOjNiWZ4cyzKgm3MWBynbTcXCDm0BHNn08-T0ZiEZFTVACx79KgCQEHAYls197hZVHVa~1VmvYCvLBrYW4AShCV7-VbX~y6fVqmdD8qEM0J-3MCSbyG3ysHopYQ4Q9tAoRGu2MZtwbOwu8fs8qpY3ARO3dmmlsAfLNistVpJd3T73wwtQMiLhmLf5N8G-MBaChyP0gS15xAnZbjxFDUIBBIgxlKguR3DdiltG0WYuwp4UpgiSZ8XvnKcuh4xnyCI8igvhYHMaHiQYakovBC4QwroqugcQXGRM5QIe7m7PogIO2pbdzpZWBg6PWyzEdE-XxQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 3.
The GQC pathway in yeast. Misfolded proteins targeted for GQC are transported to the cis-Golgi via COPII vesicles. Proteasome-targeted GQC: ER chaperones (e.g., Kar2 [in pink]) and retrieval receptors (in blue) in the cis-Golgi bind and retrieve misfolded proteins to the ER in COPI vesicles. These substrates are eliminated by ERAD-L. Lysosome/vacuole–targeted GQC: misfolded proteins that migrate to the trans-Golgi are sorted by the ESCRT/MVB pathway via Vps10 (green) or a ubiquitin ligase (e.g., Tul1). Following sorting, misfolded proteins are delivered to the vacuole.
