Figure 9. Schematic diagram summarizing key steps in the coordination of FLCN–FNIP recruitment to and function at lysosomes. 1. When amino acids are scarce, the GAP activity of GATOR1 promotes the GDP-bound state of RagA/B. 2. FLCN–FNIP are recruited to lysosomes by interacting with RagA/BGDP. 3. FLCN–FNIP exhibit GAP activity toward RagC/D.
Figure 9.

Schematic diagram summarizing key steps in the coordination of FLCN–FNIP recruitment to and function at lysosomes. 1. When amino acids are scarce, the GAP activity of GATOR1 promotes the GDP-bound state of RagA/B. 2. FLCN–FNIP are recruited to lysosomes by interacting with RagA/BGDP. 3. FLCN–FNIP exhibit GAP activity toward RagC/D.

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