Figure 1. Coordinating lumen and surface phagosome identity. The lipid kinase Vps34 generates PI(3)P on the outer leaflet of the phagosome. As the compartment matures, activation of the vATPase acidifies the lumen. Leakage of protons causes dissociation of Vps34 from the membrane, cutting off PI(3)P synthesis. A kinase necessary for PI(3)P depletion, PIKfyve, generates PI(3,5)P2 that also activates the vATPase.
Figure 1.

Coordinating lumen and surface phagosome identity. The lipid kinase Vps34 generates PI(3)P on the outer leaflet of the phagosome. As the compartment matures, activation of the vATPase acidifies the lumen. Leakage of protons causes dissociation of Vps34 from the membrane, cutting off PI(3)P synthesis. A kinase necessary for PI(3)P depletion, PIKfyve, generates PI(3,5)P2 that also activates the vATPase.

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