Figure 1. The roles of the Unc13 family in post-Golgi trafficking. Munc13-1, 2, 3, and 4 execute functions in exocytosis in different cell types. In addition, Munc13-4 acts in the homotypic fusion of secretory vesicles (Woo et al., 2017) and in the maturation of late endosomes (He et al., 2016). In this issue, Zhang et al. (2017) identify the function of BAIAP3 in endosome to TGN trafficking. All Unc13 protein members confer Ca2+ dependence to the fusion reaction they support. E, endosome; LE, late endosome; iDV, immature dense-core vesicle; DCV, mature dense-core vesicle. Drawn with inspiration from Zhang et al. (2017) to include the function of other Unc13 family members.
Figure 1.

The roles of the Unc13 family in post-Golgi trafficking. Munc13-1, 2, 3, and 4 execute functions in exocytosis in different cell types. In addition, Munc13-4 acts in the homotypic fusion of secretory vesicles (Woo et al., 2017) and in the maturation of late endosomes (He et al., 2016). In this issue, Zhang et al. (2017) identify the function of BAIAP3 in endosome to TGN trafficking. All Unc13 protein members confer Ca2+ dependence to the fusion reaction they support. E, endosome; LE, late endosome; iDV, immature dense-core vesicle; DCV, mature dense-core vesicle. Drawn with inspiration from Zhang et al. (2017) to include the function of other Unc13 family members.

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