Model of the LRRK2 RL/TRIM1 interaction. Schematic highlighting the array of downstream effects of TRIM1 binding LRRK2 RL. The phosphorylation state of S910 and S935 in the RL influences LRRK2’s preference for binding 14-3-3 versus TRIM1, which in turn alters LRRK2 localization (cytoplasm versus microtubule), ubiquitination and turnover, kinase activation by Rab29, and neuronal toxicity as measured by neurite outgrowth.