Lineage-restricted activation of Yki and JNK triggers dedifferentiation and reprogramming of syncytial AMs into VLM progenitor cells. (A) AM lineage reprogramming is induced by the nuclear activities of Ultrabithorax (Ubx) and ligand bound ecdysone receptor, thus leading to the up-regulation of org-1 and tup expression. (B) Subsequently, Org-1 and Tup promote the derepression of Yki via down-regulation of Hippo (Hpo) as well as the activation of JNK signaling. (C and D) These molecular events mediate the nuclear translocation of Yki/Sd as well as AP-1 and provoke lineage-restricted activation of Myc and piwi expression, inducing the dedifferentiation and fragmentation of the AMs into AM-derived cells (AMDCs; C) as well as the reprogramming of the AMDCs into mononucleate VLM progenitors (D). piwi is required for their redifferentiation into VLMs (not depicted).