Figure 3.
Figure 3. Tango1 is widely expressed and required for secretion in salivary glands and disc cells. (A) Expression of Tango1 in different tissues of the L3 larva (anti-Tango1 staining). (B) Localization of glue protein Sgs3 (Sgs3.GFP) in late L3 and pre-pupal salivary glands of wild-type and He>Tango1i animals. No individualized secretory granules are seen in Tango1i glands, and Sgs3.GFP remains inside cells after the onset of metamorphosis. The membrane marker myr.RFP is shown in red. (C) Confocal images of control and Tango1i wing discs expressing Hedgehog.GFP in their posterior compartment (hh>hh.GFP). (D) Confocal images of wild-type and Tango1i wing disc cells expressing secr.GFP (rn>secr.GFP).

Tango1 is widely expressed and required for secretion in salivary glands and disc cells. (A) Expression of Tango1 in different tissues of the L3 larva (anti-Tango1 staining). (B) Localization of glue protein Sgs3 (Sgs3.GFP) in late L3 and pre-pupal salivary glands of wild-type and He>Tango1i animals. No individualized secretory granules are seen in Tango1i glands, and Sgs3.GFP remains inside cells after the onset of metamorphosis. The membrane marker myr.RFP is shown in red. (C) Confocal images of control and Tango1i wing discs expressing Hedgehog.GFP in their posterior compartment (hh>hh.GFP). (D) Confocal images of wild-type and Tango1i wing disc cells expressing secr.GFP (rn>secr.GFP).

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