Mitochondrial inheritance in mitosis and meiosis. In mitosis, mitochondria remain associated with the cell cortex because of the mitochondria–plasma membrane anchoring activity of MECA. In meiosis, mitochondrial organization is remodeled: Mitochondria detach from the plasma membrane and are transmitted to spores. This meiosis-specific mitochondrial remodeling is caused by the inhibition of MECA by Ime2. As a result of Ime2-dependent phosphorylation, MECA is destroyed, and mitochondrial tethering is lost. PM, plasma membrane; P, phosphate.