Zas1 contains a conserved CHD. (A) Analysis of the Zas1 protein structure. IUPred disorder score and JPred secondary structure prediction of the CHD are indicated. (B) Distribution of C₂H₂ and Gal4-type (GAL4) ZF proteins containing a CHD during yeast evolution based on a phylogenetic tree after Corsaro et al. (2014). (C) Cartoon presentations of the S. cerevisiae Cep3 structure (PDB: 2VEQ) and a consensus model for the CHD resulting from a Phyre2 search. N- and C-terminal peripheral helices in Cep3 are shown in light and dark gray, respectively. Images created with Pymol.