OPN ablation promotes a pro-regenerative macrophage phenotype. F4/80⁺ sorted macrophages were collected from 8-wk-old mice and assessed by quantitative RT-PCR for profibrotic factors fibronectin, C-C chemokine ligand 17 (CCL17), and TGF-β (A) and pro-regenerative factors insulin-like growth factor 1 (IGF), leukemia inhibitory factor (LIF), and urokinase plasminogen activator (uPA). (B) Each sample was collected from a single mouse. The number of samples per experiment is indicated on the bars. Vertical lines indicate SEM. P-values are shown based on Student’s t test comparison.