Figure 6. AMOT-130 mutants trigger distinct effects on spine morphology. (A) Neurons expressing RFP-actin together with pEYFP, YFP–AMOT-130, YFP-AMOT-SD, or YFP-AMOT-SA. Panels show dendritic sections with RFP-actin expression. Bar, 10 µm. (B) Quantification of spine lengths. (C) Cumulative frequency plots of spine lengths. (D) Magnification of spines expressing the indicated constructs (top) and corresponding relative intensity profiles (bottom). Outlined spine heads with actin and pseudo color scale are indicated. Bar, 5 µm. (E) Bin distribution of spine head area. (F) Quantification of spine head area outlined by RFP-actin illustrated in D. Error bars represent means ± SD. *, P < 0.05; **, P < 0.01; one-way ANOVA with Tukey’s post hoc test.
Figure 6.

AMOT-130 mutants trigger distinct effects on spine morphology. (A) Neurons expressing RFP-actin together with pEYFP, YFP–AMOT-130, YFP-AMOT-SD, or YFP-AMOT-SA. Panels show dendritic sections with RFP-actin expression. Bar, 10 µm. (B) Quantification of spine lengths. (C) Cumulative frequency plots of spine lengths. (D) Magnification of spines expressing the indicated constructs (top) and corresponding relative intensity profiles (bottom). Outlined spine heads with actin and pseudo color scale are indicated. Bar, 5 µm. (E) Bin distribution of spine head area. (F) Quantification of spine head area outlined by RFP-actin illustrated in D. Error bars represent means ± SD. *, P < 0.05; **, P < 0.01; one-way ANOVA with Tukey’s post hoc test.

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