Figure 10. Schematic summary. (A) Cargo vesicles are delivered to the apical plasma membrane in dependence on Rab11a, Rab8a, and Myo5B. The v-SNARE–like Slp4a is recruited to the vesicle via Rab27, Rab8a, and Rab3b and binds the t-SNARE Stx3 together with the SM protein Munc18-2 to allow the vesicle to fuse with the plasma membrane. The v-SNARE Vamp7 interacts with Rab11a and Stx3. (B) Upon depletion of either Myo5B or Stx3, cargo vesicles are no longer delivered properly. (C) Apical cargo transport is most likely terminated via the Rab GAPs TBC1D30 and Evi5, which interact with Stx3 at the apical plasma membrane and catalyze the transition to the inactive state of Rab8a and Rab11a. (D) Overview of apical cargo proteins in WT and mislocalization upon depletion of Myo5B or Stx3.
Figure 10.

Schematic summary. (A) Cargo vesicles are delivered to the apical plasma membrane in dependence on Rab11a, Rab8a, and Myo5B. The v-SNARE–like Slp4a is recruited to the vesicle via Rab27, Rab8a, and Rab3b and binds the t-SNARE Stx3 together with the SM protein Munc18-2 to allow the vesicle to fuse with the plasma membrane. The v-SNARE Vamp7 interacts with Rab11a and Stx3. (B) Upon depletion of either Myo5B or Stx3, cargo vesicles are no longer delivered properly. (C) Apical cargo transport is most likely terminated via the Rab GAPs TBC1D30 and Evi5, which interact with Stx3 at the apical plasma membrane and catalyze the transition to the inactive state of Rab8a and Rab11a. (D) Overview of apical cargo proteins in WT and mislocalization upon depletion of Myo5B or Stx3.

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