Figure 10.
![Figure 10. Model of crinophagy. During crinophagy, excess secretory glue granules fuse with lysosomes, which requires the tethering complex HOPS (and its binding partner, PLEKHM1 [not depicted]), the activity of two small GTPases (Rab2 and Rab7), and a SNARE complex composed of Syx13 (Qa), Snap29 (Qbc), and Vamp7 (R). The degradation of secretory material also depends on proper lysosomal functioning (i.e., adequate amounts of lysosomal enzymes and an acidic pH), which is supported by the activity of the Uvrag-containing Vps34 lipid kinase complex and the v-ATPase proton (H+) pump, respectively.](https://cdn.rupress.org/rup/content_public/journal/jcb/217/1/10.1083_jcb.201702145/13/jcb_201702145_fig10.jpeg?Expires=1773558873&Signature=xVhE-9erwr6POHEf0eo5~GjHm9l3CKh5qg4-T92TVrcBdByHodufAoPN52Yyokd~4KW83Afp1pJYqWQ6cQj4V5UtLfnIMhX1moBWkjScCdmvMTAYQgj-biFv6QzMlZzx0DOxkpuOBuvCa4OivkdlH7h7BriF1SzNofHoWk550c~L7a3EYkAhwf2KZhu~o-XRNthM3i-9p3c1aj0IdkFUSjf6MHUVnokgQrPBgaVUm3iyuEkc1D~RMubpSZK1ucafNzmzdHs0PCJTRMSJdrjgNH-LeDUOYs1Njvt9rSsDWkJQgGuZqubd5t1gqVkyOtITvTAx24khoFOz80cO~-6c2A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Model of crinophagy. During crinophagy, excess secretory glue granules fuse with lysosomes, which requires the tethering complex HOPS (and its binding partner, PLEKHM1 [not depicted]), the activity of two small GTPases (Rab2 and Rab7), and a SNARE complex composed of Syx13 (Qa), Snap29 (Qbc), and Vamp7 (R). The degradation of secretory material also depends on proper lysosomal functioning (i.e., adequate amounts of lysosomal enzymes and an acidic pH), which is supported by the activity of the Uvrag-containing Vps34 lipid kinase complex and the v-ATPase proton (H+) pump, respectively.
