Model for role of TORC2-Ypk1 and mitochondria in regulating autophagy after amino acid starvation. When active, TORC2 and Ypk1 promote healthy mitochondrial function, which is required for the GAAC response and subsequent induction of autophagy after amino acid starvation. Decreased TORC2-Ypk1 signaling leads to aberrant mitochondrial respiration and increased mitochondrial ROS, which activates calcineurin via the ER/PM-localized calcium-channel component, Mid1. Hyperactive calcineurin in turn negatively regulates the GAAC response and blocks autophagy under conditions of amino acid starvation.