Figure 1.
Figure 1. A schematic drawing shows the transverse section of the core-shell spheroid paraspeckle structure. Under SIM, the paraspeckle structure can be divided into two parts, the core and the shell. The core of paraspeckles contains the middle region of Neat1_2 (shown as Neat1_mid) and proteins SFPQ, PSPC1, NONO, and FUS. The 5′ and 3′ ends of Neat1_2 (shown as Neat1_5′+3′) and the protein TDP43 are located in the shell of paraspeckles. Proteins RBM14 and BRG1, defined by West et al. (2016) as patch proteins, are located in both the core and the shell of paraspeckles. FUS proteins assemble the paraspeckle-like core units and patch/shell proteins into paraspeckle spheroids. The AG-rich RNAs are enriched in the surface of paraspeckles, whereas the previously reported inverted repeats containing mRNAs interact with the core proteins and are proposed to localize in the middle of paraspeckles.

A schematic drawing shows the transverse section of the core-shell spheroid paraspeckle structure. Under SIM, the paraspeckle structure can be divided into two parts, the core and the shell. The core of paraspeckles contains the middle region of Neat1_2 (shown as Neat1_mid) and proteins SFPQ, PSPC1, NONO, and FUS. The 5′ and 3′ ends of Neat1_2 (shown as Neat1_5′+3′) and the protein TDP43 are located in the shell of paraspeckles. Proteins RBM14 and BRG1, defined by West et al. (2016) as patch proteins, are located in both the core and the shell of paraspeckles. FUS proteins assemble the paraspeckle-like core units and patch/shell proteins into paraspeckle spheroids. The AG-rich RNAs are enriched in the surface of paraspeckles, whereas the previously reported inverted repeats containing mRNAs interact with the core proteins and are proposed to localize in the middle of paraspeckles.

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