A model of bulk macroautophagy, mitophagy, and MDV-mediated selective mitochondrial protein turnover in mammalian cells. During bulk macroautophagy, Atg proteins mediate the formation of double-membrane autophagosomes, which subsequently acquire Syntaxin-17 and HOPS to enable their fusion with lysosomes and late endosomes. Mitophagy requires the actions of parkin, PINK1, and Atg proteins to promote formation of mitochondria-containing autophagosomes, which fuse with endolysosomes in a HOPS-dependent but Syntaxin-17–independent fashion. Parkin and PINK1 also mediate the stress-induced budding of MDVs from mitochondria, which fuse with endolysosomes in a Syntaxin-17– and HOPS-dependent manner.