FOCAL POINT  (Left to right) Kai Liu, Chonglin Yang, Youli Jian, and colleagues investigated how maturing early endosomes control levels of PtdIns3P. They determined that sorf-1 and sorf-2 spur early endosomes to replace PtdIns3P. If endosomes don’t swap out PtdIns3P, intracellular trafficking is disrupted. Time-lapse imaging shows that normal endosomes (green) rapidly pass on the red dye TR-BSA (top row). But enlarged endosomes lacking sorf-1 and sorf-2 (bottom row) retain the compound. / PHOTO COURTESY OF YUDONG JIN

FOCAL POINT  (Left to right) Kai Liu, Chonglin Yang, Youli Jian, and colleagues investigated how maturing early endosomes control levels of PtdIns3P. They determined that sorf-1 and sorf-2 spur early endosomes to replace PtdIns3P. If endosomes don’t swap out PtdIns3P, intracellular trafficking is disrupted. Time-lapse imaging shows that normal endosomes (green) rapidly pass on the red dye TR-BSA (top row). But enlarged endosomes lacking sorf-1 and sorf-2 (bottom row) retain the compound.

PHOTO COURTESY OF YUDONG JIN

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