Figure 3. Immunolocalization of TOPII (red) and ASY1 (green) in WT (Ws) prophase I meiocytes using SIM. (A) Zygotene stage. Arrows indicate four regions of TOPII accumulation (red) that localize with axis entanglements (green). (B) Zoomed region of synapsed axis in Ws. (C) Zoomed entangled region with a broken lateral element (green; arrow). (D) Zoomed entanglement region with a high accumulation of TOPII. (E) Representative examples of “closed” and “open” interlock configurations in topII-1 and topII-1hom nup136-2het metaphase I cells and magnified models. Bars, 5 μm.
Figure 3.

Immunolocalization of TOPII (red) and ASY1 (green) in WT (Ws) prophase I meiocytes using SIM. (A) Zygotene stage. Arrows indicate four regions of TOPII accumulation (red) that localize with axis entanglements (green). (B) Zoomed region of synapsed axis in Ws. (C) Zoomed entangled region with a broken lateral element (green; arrow). (D) Zoomed entanglement region with a high accumulation of TOPII. (E) Representative examples of “closed” and “open” interlock configurations in topII-1 and topII-1hom nup136-2het metaphase I cells and magnified models. Bars, 5 μm.

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