Figure 5.
Figure 5. Ablation of Sam68 rescues motor neuron loss in the spinal cord of SMAΔ7 mice. (A) Schematic representation of a Nissl-stained spinal cord section of the lumbar spinal cord from 8-dpp non-SMA mice (right). The red circle highlights the ventral horn of the spinal cord analyzed. Bar, 250 µm. (B) Higher magnification of sections of the ventral lumbar spinal cord from 8-dpp non-SMA, SMAΔ7/Sam68+/+, and SMAΔ7/Sam68−/− (SMA) mice. Motor neurons are indicated by arrowheads. Bar, 125 µm. (C) Bar graph representing motor neuron counts (mean ± SD; n = 3) in lumbar spinal cord from mice described in B. Statistical analysis was performed by one-way ANOVA test followed by Bonferroni’s multiple comparison posttest (***, P < 0.001; ****, P < 0.0001).

Ablation of Sam68 rescues motor neuron loss in the spinal cord of SMAΔ7 mice. (A) Schematic representation of a Nissl-stained spinal cord section of the lumbar spinal cord from 8-dpp non-SMA mice (right). The red circle highlights the ventral horn of the spinal cord analyzed. Bar, 250 µm. (B) Higher magnification of sections of the ventral lumbar spinal cord from 8-dpp non-SMA, SMAΔ7/Sam68+/+, and SMAΔ7/Sam68−/− (SMA) mice. Motor neurons are indicated by arrowheads. Bar, 125 µm. (C) Bar graph representing motor neuron counts (mean ± SD; n = 3) in lumbar spinal cord from mice described in B. Statistical analysis was performed by one-way ANOVA test followed by Bonferroni’s multiple comparison posttest (***, P < 0.001; ****, P < 0.0001).

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