Schematic model showing that PGAM1 promotes HR repair in a metabolic-dependent manner. Imbalance of dNTP caused by PGAM1 inhibition promotes the translocation of p53 into nuclei and in turn activates p21 in p53 WT cancer cells, where p73 functions as a p53 counterpart in p53 inactive cells. Up-regulated p21 leads to CtIP degradation by activating the APC/C-Cdh1 complex and thereby impairing HR repair.