Figure 2. Graded and switch-like... | Rockefeller University Press

Figure 2.

$Figure 2. Graded and switch-like features of the pheromone response. (A) Schematic of a switch-like and graded response to pheromone. (B) Schematic of how noise results in a distribution of outputs for both graded and switch-like responses. Note the presence of bimodal distributions in the switch-like response. (C, top) Simplified network schematic of the interaction of the G1/S cell cycle control network and the pheromone-dependent MAPK pathway. (Bottom left) Illustration of the graded response of MAPK pathway outputs, such as the fraction of Fus3 that is active or the Ste12-dependent transcription rate. (Bottom right) Illustration of how the graded pheromone pathway output is converted to a switch-like cell cycle response by multiple positive feedback loops in the cell cycle network.$

Graded and switch-like features of the pheromone response. (A) Schematic of a switch-like and graded response to pheromone. (B) Schematic of how noise results in a distribution of outputs for both graded and switch-like responses. Note the presence of bimodal distributions in the switch-like response. (C, top) Simplified network schematic of the interaction of the G1/S cell cycle control network and the pheromone-dependent MAPK pathway. (Bottom left) Illustration of the graded response of MAPK pathway outputs, such as the fraction of Fus3 that is active or the Ste12-dependent transcription rate. (Bottom right) Illustration of how the graded pheromone pathway output is converted to a switch-like cell cycle response by multiple positive feedback loops in the cell cycle network.