Figure 9. Model of the GEF-H1–mediated response to shear stress. Shear stress induces dephosphorylation of GEF-H1 and relocalization from the MT array into the uropod. The dephosphorylated form of GEF-H1 is catalytically active and drives actomyosin-based contraction through Rho-mediated MLC phosphorylation. Although integrins (not depicted) are likely to play an important role in the shear stress response, their role in signaling to GEF-H1 is unclear.
Figure 9.

Model of the GEF-H1–mediated response to shear stress. Shear stress induces dephosphorylation of GEF-H1 and relocalization from the MT array into the uropod. The dephosphorylated form of GEF-H1 is catalytically active and drives actomyosin-based contraction through Rho-mediated MLC phosphorylation. Although integrins (not depicted) are likely to play an important role in the shear stress response, their role in signaling to GEF-H1 is unclear.

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