Figure 5. B2AR localization to ASRT domains correlates with expression of endosomal cAMP-specific genes. (A–C) Tukey box plots of fold change in PCK1 (A), CGA (B), and NR4A1 (C) expression across multiple experimental replicates. Iso increased PCK1 expression. Dynasore, Dyngo-4a, dynamin-K44A, or latA prevented the iso-induced increase in PCK1 expression. n = 11 for iso, iso + dynasore, and iso + latA, and n = 6 for all others. (D–F) Fold change in PCK1 (D), CGA (E), and NR4A1 (F) expression with iso for B2AR, SS>AA, and SS>DD. Iso increased PCK1 expression for B2AR and SS>DD, but not for SS>AA. n = 14 for B2AR and SS>AA, and n = 6 for SS>DD. Dashed lines throughout indicate the location of value 1 on the y axis. In all cases, p-values in relation to iso treatment alone are shown.
Figure 5.

B2AR localization to ASRT domains correlates with expression of endosomal cAMP-specific genes. (A–C) Tukey box plots of fold change in PCK1 (A), CGA (B), and NR4A1 (C) expression across multiple experimental replicates. Iso increased PCK1 expression. Dynasore, Dyngo-4a, dynamin-K44A, or latA prevented the iso-induced increase in PCK1 expression. n = 11 for iso, iso + dynasore, and iso + latA, and n = 6 for all others. (D–F) Fold change in PCK1 (D), CGA (E), and NR4A1 (F) expression with iso for B2AR, SS>AA, and SS>DD. Iso increased PCK1 expression for B2AR and SS>DD, but not for SS>AA. n = 14 for B2AR and SS>AA, and n = 6 for SS>DD. Dashed lines throughout indicate the location of value 1 on the y axis. In all cases, p-values in relation to iso treatment alone are shown.

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