Figure 6.
Figure 6. Cortactin overexpression compensates for Rab27a loss. (A) WB analysis of SCC61 control (shLacZ), Rab27a-KD1 (R27aKD1), cortactin-overexpressed (OE shLacZ), and cortactin-overexpressed cells knocked down for Rab27a (OE R27aKD1). Numbers indicate Rab27 levels normalized to β-actin levels, as a fraction of control. (B) NTA quantitation of exosomes secreted from the indicated cell lines. n ≥ 3 independent experiments. Bar graphs = mean ± SE. *, P < 0.05; **, P < 0.01 compared with shLacZ; #, P < 0.05; ##, P < 0.01 compared with R27aKD1/shLacZ, analyzed by Student’s t test.

Cortactin overexpression compensates for Rab27a loss. (A) WB analysis of SCC61 control (shLacZ), Rab27a-KD1 (R27aKD1), cortactin-overexpressed (OE shLacZ), and cortactin-overexpressed cells knocked down for Rab27a (OE R27aKD1). Numbers indicate Rab27 levels normalized to β-actin levels, as a fraction of control. (B) NTA quantitation of exosomes secreted from the indicated cell lines. n ≥ 3 independent experiments. Bar graphs = mean ± SE. *, P < 0.05; **, P < 0.01 compared with shLacZ; #, P < 0.05; ##, P < 0.01 compared with R27aKD1/shLacZ, analyzed by Student’s t test.

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