Cartoon model of SLIT2/ROBO1 signaling circuit. (1) Increased ECM stiffness down-regulates miR-203 derepressing Robo1. (2) ROBO1 expression is increased. (3) SLIT2/ROBO1 signals through Sos1/Rac to activate FAK; Rac also contributes to NMII activation. (4) This results in FA maturation and (5) enhanced cell contractility.