USP10 binding to G3BP regulates SG condensation by inhibiting a G3BP-mediated condensation event. Stress promotes polysome disassembly, thus exposing mRNA and converting polysomes into mRNPs. G3BP shuttles between two different phases, promoting a similar state change in 40S subunits, Caprin1, and their bound mRNAs. USP10 binding to G3BP stabilizes a soluble conformation of G3BP bound to 40S subunits (via G3BP C terminus) and to PABP (through USP10), causing SG disassembly. Some SG-associated factors, such as eIF3, remain in the cytoplasmic soluble state, but accumulate in the SG as individual mRNPs are mobilized back into active translation. For further details, see the Discussion section.