Figure 2.
Figure 2. Slow myofiber number is reduced in adult ephrin-A3−/− mice. (A) Immunohistochemistry showing laminin (red) and MyHC-I (green) expression in transverse cryosections from uninjured TA (T) and EDL (E) muscles of an adult ephrin-A3−/− mouse. (B) Immunohistochemistry showing laminin (red) and MyHC-I (green) expression in transverse cryosections from uninjured gastrocnemius (G), plantaris (P), and soleus (S) muscles of an adult ephrin-A3−/− mouse. Inset areas are enlarged at right (yellow, top; cyan, bottom). (C) All but one muscle scored had significantly fewer MyHC-I+ve myofibers in ephrin-A3−/− mice than age-matched wild type. P = 0.029 (TA); 0.0001 (EDL); 0.0035 (gastrocnemius); and 0.034 (plantaris). Error bars represent SEM. The change in MyHC-I+ve myofibers in the soleus is not significant. *, P < 0.05; **, P < 0.005; ***, P < 0.0005. Bars: (montages) 500 µm; (insets) 300 µm. n ≥ 3.

Slow myofiber number is reduced in adult ephrin-A3−/− mice. (A) Immunohistochemistry showing laminin (red) and MyHC-I (green) expression in transverse cryosections from uninjured TA (T) and EDL (E) muscles of an adult ephrin-A3−/− mouse. (B) Immunohistochemistry showing laminin (red) and MyHC-I (green) expression in transverse cryosections from uninjured gastrocnemius (G), plantaris (P), and soleus (S) muscles of an adult ephrin-A3−/− mouse. Inset areas are enlarged at right (yellow, top; cyan, bottom). (C) All but one muscle scored had significantly fewer MyHC-I+ve myofibers in ephrin-A3−/− mice than age-matched wild type. P = 0.029 (TA); 0.0001 (EDL); 0.0035 (gastrocnemius); and 0.034 (plantaris). Error bars represent SEM. The change in MyHC-I+ve myofibers in the soleus is not significant. *, P < 0.05; **, P < 0.005; ***, P < 0.0005. Bars: (montages) 500 µm; (insets) 300 µm. n ≥ 3.

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