FOCAL POINT  (Top, left to right) Zheng Wang, Kaleb Naegeli, Lara Linden, David Sherwood, and colleagues (not pictured) describe how netrin polarizes its receptor UNC-40 in order to direct the invasion of the C. elegans anchor cell. In the absence of netrin, UNC-40 is active and clusters at the cell surface. UNC-40 clusters undergo cycles of assembly and disassembly at random positions around the cell (see time-lapse series, bottom). Netrin stabilizes clusters at the basal surface of the cell to promote the formation of an invasive protrusion that penetrates the underlying basement membrane. / PHOTOS COURTESY OF ZHENG WANG AND DAVID SHERWOOD

FOCAL POINT  (Top, left to right) Zheng Wang, Kaleb Naegeli, Lara Linden, David Sherwood, and colleagues (not pictured) describe how netrin polarizes its receptor UNC-40 in order to direct the invasion of the C. elegans anchor cell. In the absence of netrin, UNC-40 is active and clusters at the cell surface. UNC-40 clusters undergo cycles of assembly and disassembly at random positions around the cell (see time-lapse series, bottom). Netrin stabilizes clusters at the basal surface of the cell to promote the formation of an invasive protrusion that penetrates the underlying basement membrane.

PHOTOS COURTESY OF ZHENG WANG AND DAVID SHERWOOD

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