Figure 9. Reduced TGF-β1 and phospho-SMAD2/3 expression in the FOXO1-deleted mice keratinocytes. Paraffin-embedded cross sections from K14.Cre−.FOXO1L/L and K14.Cre+.FOXO1L/L mice were analyzed by immunofluorescence using (A) anti–TGF-β1 antibody, (C) phospho-SMAD2/3 antibody, and (E) anti-SMAD2/3 antibody. Quantitative analysis of (B) TGF-β1–positive keratinocytes, (D) phospho-SMAD2/3–positive keratinocytes, and (F) SMAD2/3-positive keratinocytes. Bar, 100 µm. EP, epidermis; CT, connective tissues. White dashed lines demarcate the epidermis from the dermis. Each value is the mean ± SEM for n = 6–9 mice per group. Asterisks indicate significant changes compared with control mice (P < 0.05).
Figure 9.

Reduced TGF-β1 and phospho-SMAD2/3 expression in the FOXO1-deleted mice keratinocytes. Paraffin-embedded cross sections from K14.Cre−.FOXO1L/L and K14.Cre+.FOXO1L/L mice were analyzed by immunofluorescence using (A) anti–TGF-β1 antibody, (C) phospho-SMAD2/3 antibody, and (E) anti-SMAD2/3 antibody. Quantitative analysis of (B) TGF-β1–positive keratinocytes, (D) phospho-SMAD2/3–positive keratinocytes, and (F) SMAD2/3-positive keratinocytes. Bar, 100 µm. EP, epidermis; CT, connective tissues. White dashed lines demarcate the epidermis from the dermis. Each value is the mean ± SEM for n = 6–9 mice per group. Asterisks indicate significant changes compared with control mice (P < 0.05).

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