Figure 7. Delayed wound healing in keratinocyte-specific FOXO1-deleted mice. (A) Hematoxylin and eosin (H&E) staining of K14.Cre−.FOXO1L/L and K14.Cre+.FOXO1L/L mice wound biopsies on day 4 after wounding. Bar, 500 µm. WC, wound center; WE, wound epithelium; Normal, normal epithelium. Quantification of epithelial migration and re-epithelialization in the day-4 and day-7 scalp wounds. The gap between epithelium (B and F), number of cells in the wound epithelium (C and G), epithelial area (D and H), and epithelial thickness (E and I) was assessed by image analysis of H&E-stained sections at the center of each wound. EP, epidermis; CT, connective tissues. Each value is the mean ± SEM for n = 6–9 mice per group. Asterisks indicate significant increase or decrease compared with control mice (P < 0.05).
Figure 7.

Delayed wound healing in keratinocyte-specific FOXO1-deleted mice. (A) Hematoxylin and eosin (H&E) staining of K14.Cre−.FOXO1L/L and K14.Cre+.FOXO1L/L mice wound biopsies on day 4 after wounding. Bar, 500 µm. WC, wound center; WE, wound epithelium; Normal, normal epithelium. Quantification of epithelial migration and re-epithelialization in the day-4 and day-7 scalp wounds. The gap between epithelium (B and F), number of cells in the wound epithelium (C and G), epithelial area (D and H), and epithelial thickness (E and I) was assessed by image analysis of H&E-stained sections at the center of each wound. EP, epidermis; CT, connective tissues. Each value is the mean ± SEM for n = 6–9 mice per group. Asterisks indicate significant increase or decrease compared with control mice (P < 0.05).

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