Figure 3. TYRP1 accumulates in the Golgi of BLOC-2− melanocytes. (a and b) Immunoelectron microscopy of ultrathin cryosections from BLOC-2− (a) and BLOC-2R (b) melanocytes that were immunogold labeled for TYRP1 using10-nm protein A gold (TYRP1 10) and for ATP7A using 15-nm protein A gold (ATP7A 15). GA, Golgi apparatus; II and IV, stage II and IV melanosomes. Arrows show examples of TYRP1 labeling in the Golgi and stage IV melanosomes in BLOC-2− melanocytes (a) and on stage IV melanosomes in BLOC-2R cells (b); note labeling on tubular and vacuolar endosomes in both cell types. Arrowheads show examples of ATP7A labeling on the Golgi and melanosomes in both cell types. Bars, 500 nm.
Figure 3.

TYRP1 accumulates in the Golgi of BLOC-2− melanocytes. (a and b) Immunoelectron microscopy of ultrathin cryosections from BLOC-2− (a) and BLOC-2R (b) melanocytes that were immunogold labeled for TYRP1 using10-nm protein A gold (TYRP1 10) and for ATP7A using 15-nm protein A gold (ATP7A 15). GA, Golgi apparatus; II and IV, stage II and IV melanosomes. Arrows show examples of TYRP1 labeling in the Golgi and stage IV melanosomes in BLOC-2− melanocytes (a) and on stage IV melanosomes in BLOC-2R cells (b); note labeling on tubular and vacuolar endosomes in both cell types. Arrowheads show examples of ATP7A labeling on the Golgi and melanosomes in both cell types. Bars, 500 nm.

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