FOCAL POINT  Dana Graves (left), Chenying Zhang (right), and colleagues (not pictured) determined that high sugar levels impair tissue repair by changing the function of FOXO1. In skin from mice with normal glucose levels (top row), more keratinocytes (red) migrate into damaged tissue in control mice (left) than in mice lacking FOXO1 (right). But in diabetic mice (bottom row), more keratinocytes migrate into the wound in animals lacking FOXO1 (right) than in controls (left). In all four images, blue marks cell nuclei, and the dotted line delineates the boundary between the epidermis and the dermis.

PHOTOS COURTESY OF THE AUTHORS