Figure 3.
Figure 3. The reported location of extracellular matrix-degrading proteases in human cancer depends on detection method. (A) Compilation of expression localization data for MMP-1, MMP-2, MMP-13, MMP-14, and uPA in breast and colon cancer divided into in situ hybridization studies (ISH) and IHC or IF studies (IHC/IF). The bar graphs show the number of studies reporting the expression of any of the proteases in stromal cells only, both cancer and stromal cells, and cancer cells only. (B) Compilation of expression localization data for MMP-1, MMP-2, MMP-13, MMP-14, and uPA in breast and colon cancer divided into radioprobe in situ hybridization studies and nonradioprobe in situ studies. The bar graphs show the number of studies reporting the expression of any of the proteases in stromal cells only, both cancer and stromal cells, and cancer cells only.

The reported location of extracellular matrix-degrading proteases in human cancer depends on detection method. (A) Compilation of expression localization data for MMP-1, MMP-2, MMP-13, MMP-14, and uPA in breast and colon cancer divided into in situ hybridization studies (ISH) and IHC or IF studies (IHC/IF). The bar graphs show the number of studies reporting the expression of any of the proteases in stromal cells only, both cancer and stromal cells, and cancer cells only. (B) Compilation of expression localization data for MMP-1, MMP-2, MMP-13, MMP-14, and uPA in breast and colon cancer divided into radioprobe in situ hybridization studies and nonradioprobe in situ studies. The bar graphs show the number of studies reporting the expression of any of the proteases in stromal cells only, both cancer and stromal cells, and cancer cells only.

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