Figure 1. Schematic of platelet production. (1) HSCs in the bone marrow differentiate into MKs in a TPO-dependent manner. (2) MKs undergo endomitosis and develop nuclei ranging in DNA content from 2n to 128n. (3) As MKs mature, they develop a highly invaginated membrane throughout their cytoplasm, which is continuous with the external plasma membrane. This membrane serves as a reservoir for proplatelet formation. (4) MKs migrate to the vascular niche, where they extend proplatelets and release them into vascular sinusoids. The entire MK is converted into pre/proplatelets, and its nucleus is exuded and phagocytosed. (5) Once in the bloodstream, proplatelets interconvert into preplatelets. (6) A fission event creates two platelets from a barbell proplatelet.
Figure 1.

Schematic of platelet production. (1) HSCs in the bone marrow differentiate into MKs in a TPO-dependent manner. (2) MKs undergo endomitosis and develop nuclei ranging in DNA content from 2n to 128n. (3) As MKs mature, they develop a highly invaginated membrane throughout their cytoplasm, which is continuous with the external plasma membrane. This membrane serves as a reservoir for proplatelet formation. (4) MKs migrate to the vascular niche, where they extend proplatelets and release them into vascular sinusoids. The entire MK is converted into pre/proplatelets, and its nucleus is exuded and phagocytosed. (5) Once in the bloodstream, proplatelets interconvert into preplatelets. (6) A fission event creates two platelets from a barbell proplatelet.

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