FOCAL POINT (Top row, left to right) Claudia Baumann, Rabindranath De La Fuente, John Schimenti, and colleagues (not pictured) pin down the different functions of the histone-binding protein BRWD1 in sperm and eggs. (Bottom row) In eggs from control mice, chromosomes display a tidy formation (left). But chromosomes in eggs lacking BRWD1 are often long or broken (center) and don’t separate properly (right). In contrast, BRWD1’s main function in sperm is to regulate gene expression.
PHOTOS COURTESY OF CHRISTOPHER B. HERRON (BAUMANN/DE LA FUENTE) AND KERRY SCHIMENTI