DDR1 controls linear invadosome formation via Tuba-dependent Cdc42 activation. Schematic representation of linear invadosome architecture and molecular composition. When cells are seeded on fibrillar type I collagen, DDR1 is activated along the fibrils, leading to the activation of Cdc42 via Tuba GEF and recruiting classical components of invadopodia such as N-WASP, cortactin, and scaffold protein Tks5 to form linear invadosomes. Linear invadosomes are able to degrade extracellular matrix elements via MT1-MMP and MMP2 (Juin et al., 2012).