Interactome analysis of nuclear foci proteome. (A–E) A random selected protein from each nuclear subcompartment was used as the bait for tandem affinity purification and mass spectrometry analysis. The protein–protein interaction networks characterized for Fam76B (nuclear speckles; A), ZBTB45 (PML bodies; B), PHC2 (Polycomb bodies; C), KHDRBS3 (Sam68 nuclear bodies; D), or ZNF24 (paraspeckles; E) are presented in the cartoon (please also see Table S7).