FOCAL POINT Two groups of scientists describe how the Aurora B kinase controls the size of anaphase central spindles by regulating two different kinesin motor proteins. (Top row, left to right) Sapan Gandhi, Ricardo Nunes Bastos, Ryan Baron, Francis Barr, and colleagues (not pictured) demonstrate that Aurora B promotes the recruitment and activation of KIF4A (red) at the spindle midzone (green), where it suppresses the growth of microtubule plus ends. Meanwhile, (bottom row) Ryota Uehara (left), Gohta Goshima (right), and colleagues (not pictured) reveal that Aurora B restricts Kif2a (red) to the distal ends of the central spindle, where it depolymerizes the minus ends of microtubules (green). Both kinesins are regulated by the pool of Aurora B that forms a phosphorylation gradient emanating from the spindle midzone. / BARR LAB PHOTO COURTESY OF LARS LANGEMEYER; UEHARA AND GOSHIMA PHOTO COURTESY OF THE AUTHORS.

FOCAL POINT Two groups of scientists describe how the Aurora B kinase controls the size of anaphase central spindles by regulating two different kinesin motor proteins. (Top row, left to right) Sapan Gandhi, Ricardo Nunes Bastos, Ryan Baron, Francis Barr, and colleagues (not pictured) demonstrate that Aurora B promotes the recruitment and activation of KIF4A (red) at the spindle midzone (green), where it suppresses the growth of microtubule plus ends. Meanwhile, (bottom row) Ryota Uehara (left), Gohta Goshima (right), and colleagues (not pictured) reveal that Aurora B restricts Kif2a (red) to the distal ends of the central spindle, where it depolymerizes the minus ends of microtubules (green). Both kinesins are regulated by the pool of Aurora B that forms a phosphorylation gradient emanating from the spindle midzone.

BARR LAB PHOTO COURTESY OF LARS LANGEMEYER; UEHARA AND GOSHIMA PHOTO COURTESY OF THE AUTHORS.

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