Figure 4.
Figure 4. The STIM1 mutants with enhanced binding recruit SARAF to the plasma membrane. CFP-tagged STIM1 and deletion constructs and GFP-tagged SARAF were expressed in HEK cells and imaged after 16–24 h. The images show that STIM1Δ447–460 and STIM1Δ475–490 localize in the plasma membrane and recruit SARAF. STIM1Δ448–530 also localizes to the plasma membrane but does not affect SARAF localization. Bars, 5 µm.

The STIM1 mutants with enhanced binding recruit SARAF to the plasma membrane. CFP-tagged STIM1 and deletion constructs and GFP-tagged SARAF were expressed in HEK cells and imaged after 16–24 h. The images show that STIM1Δ447–460 and STIM1Δ475–490 localize in the plasma membrane and recruit SARAF. STIM1Δ448–530 also localizes to the plasma membrane but does not affect SARAF localization. Bars, 5 µm.

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