Figure 6. USH1 proteins in the calyceal processes of macaque and human photoreceptors. (A) Confocal cross-sections of rod (top panels), and cone (bottom panels) photoreceptors at the level of the connecting cilium (CC) from flat-mount macaque retinas. The five USH1 proteins—myosin VIIa, harmonin, cadherin-23, protocadherin-15, sans—display punctate patterns of staining around the base of the outer segment. The microfilament (F-actin) and microtubule (glutamylated tubulin) cytoskeletons are labeled in red and blue, respectively. (B) In longitudinal sections of a human retina, protocadherin-15 is detected along the calyceal processes (CP). Intense labeling is observed at the inner–outer segment junction in rod photoreceptors (arrows). Myosin VIIa, harmonin, cadherin-23, and sans also are detected along the calyceal processes. IS, inner segment. Bars, 2 µm.
Figure 6.

USH1 proteins in the calyceal processes of macaque and human photoreceptors. (A) Confocal cross-sections of rod (top panels), and cone (bottom panels) photoreceptors at the level of the connecting cilium (CC) from flat-mount macaque retinas. The five USH1 proteins—myosin VIIa, harmonin, cadherin-23, protocadherin-15, sans—display punctate patterns of staining around the base of the outer segment. The microfilament (F-actin) and microtubule (glutamylated tubulin) cytoskeletons are labeled in red and blue, respectively. (B) In longitudinal sections of a human retina, protocadherin-15 is detected along the calyceal processes (CP). Intense labeling is observed at the inner–outer segment junction in rod photoreceptors (arrows). Myosin VIIa, harmonin, cadherin-23, and sans also are detected along the calyceal processes. IS, inner segment. Bars, 2 µm.

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