Figure 9. C. elegans MIB1 RNAi genetically interacts with lin-18/RYK. (A) Phylogram representing the relationship of ceMIB to the top four hits from a BLASTp analysis of the human proteome. (B) Quantification of the bivulva phenotype from three independent RNAi feeding experiments. *, P < 0.0001; #, P < 0.05, Fisher’s exact test. (C–F) Images of L4 stage C. elegans larvae. ceMIB RNAi, mutation in lin-18/RYK, or the combination of both results in the bivulva phenotype characteristic of abnormal vulva cell fate specification. Anterior is to the left and dorsal is up. Arrowheads indicate vulval invaginations. Bar, 10 µm.
Figure 9.

C. elegans MIB1 RNAi genetically interacts with lin-18/RYK. (A) Phylogram representing the relationship of ceMIB to the top four hits from a BLASTp analysis of the human proteome. (B) Quantification of the bivulva phenotype from three independent RNAi feeding experiments. *, P < 0.0001; #, P < 0.05, Fisher’s exact test. (C–F) Images of L4 stage C. elegans larvae. ceMIB RNAi, mutation in lin-18/RYK, or the combination of both results in the bivulva phenotype characteristic of abnormal vulva cell fate specification. Anterior is to the left and dorsal is up. Arrowheads indicate vulval invaginations. Bar, 10 µm.

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