Association of membrane-deforming machineries with the endomembrane system. An overview of a generic eukaryotic endomembrane system, with major compartments, endosomes, and exocytic/endocytic pathways, is shown. The diagram is highly schematic and is used to represent the major organelles, exocytic and endocytic pathways present in a great many eukaryotes—specific lineage-specific features are omitted for clarity. Arrows show known and presumed major trafficking routes and their directions—again the representation is generic and not all routes operate in all cells. Membranes are colored to illustrate the participation of major protocoatomer (red), ESCRT (green), and BAR (blue) domain-associated complexes.