Figure 2. Acetylation regulates the catalytic activity of metabolic enzymes. Acetylation can regulate the catalytic activity of metabolic enzymes through directly neutralizing the positive charge of lysine residues in the active site of OTC (A), recruiting a negative regulator such as phosphatase (PPase) to inhibit GP (B), or causing allosteric changes in 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2; C). Enzymes, acetylated lysine residues (K), and active sites are labeled as in Fig. 1. S, substrate.
Figure 2.

Acetylation regulates the catalytic activity of metabolic enzymes. Acetylation can regulate the catalytic activity of metabolic enzymes through directly neutralizing the positive charge of lysine residues in the active site of OTC (A), recruiting a negative regulator such as phosphatase (PPase) to inhibit GP (B), or causing allosteric changes in 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2; C). Enzymes, acetylated lysine residues (K), and active sites are labeled as in Fig. 1. S, substrate.

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