FOCAL POINT  (Left to right) Bruce Mayer, Jonathon Ditlev, Leslie Loew, and colleagues (not pictured) explored the dynamics of the actin-polymerizing Nck proteins. When fusion proteins that contain Nck domains (red, right) cluster at the plasma membrane, cells grow comet tails of actin (green). The inset shows a close-up of a comet tail and a model tail from the researchers’ simulations. The team found that Nck proteins are most effective at triggering actin polymerization if they are at high density and at a 4:2:1 ratio with N-WASp and the Arp2/3 complex. / PHOTO COURTESY OF COREY ADLER; CELL IMAGE COURTESY OF JONATHON DITLEV

FOCAL POINT  (Left to right) Bruce Mayer, Jonathon Ditlev, Leslie Loew, and colleagues (not pictured) explored the dynamics of the actin-polymerizing Nck proteins. When fusion proteins that contain Nck domains (red, right) cluster at the plasma membrane, cells grow comet tails of actin (green). The inset shows a close-up of a comet tail and a model tail from the researchers’ simulations. The team found that Nck proteins are most effective at triggering actin polymerization if they are at high density and at a 4:2:1 ratio with N-WASp and the Arp2/3 complex.

PHOTO COURTESY OF COREY ADLER; CELL IMAGE COURTESY OF JONATHON DITLEV

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